目的：探讨无创机械通气对慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)呼吸衰竭患者中枢呼吸驱动的影响。方法：研究组AECOPD伴呼吸衰竭患者40例(男22例，女18例)，平均年龄67.5±7.5岁，在综合治疗基础上应用无创机械通气。同期对照组AECOPD伴呼吸衰竭患者48例（男25例，女23例）平均年龄65.03±8.25岁,因各种原因仅行综合治疗。上述两组分别测定急性发作期、缓解期中枢呼吸驱动（P0.1），同时检测患者急性发作期与缓解期白天的血气情况。结果：研究组患者的P0.1在急性发作期为0.446 ±0.008 Kpa，缓解期为0.325 ±0.105 Kpa,病情缓解时间为13±2天.对照组患者P0.1急性发作期为0.446±0.002 Kpa，缓解期为0.338±0.001 Kpa,病情缓解时间为18±3天.两组急性发作期的P0.1均高于缓解期，差别有统计学意义（P＜0.05）。缓解期P0.1两组比较研究组较对照组下降,提示无创通气治疗可降低COPD患者的中枢呼吸驱动。结论：中枢呼吸驱动在COPD急性加重期较缓解期增高，无创机械通气对COPD呼衰患者中枢呼吸驱动改善可能起一定的作用。

Objective: To investigate the non-invasive mechanical ventilation for chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD) patients with respiratory failure the effects of central respiratory drive. Methods: The study group AECOPD with 40 cases of patients with respiratory failure (22 cases of male, female 18 cases), the average age of 67.5 ± 7.5 years old, in the comprehensive treatment based on the application of non-invasive mechanical ventilation. AECOPD with the same period in the control group 48 cases of respiratory failure patients (male 25, female 23 cases) the average age of 65.03 ± 8.25 years old, for various reasons only comprehensive treatment of line. Determination of the above-mentioned two groups, respectively, acute stage, remission of central respiratory drive (P0.1), while detection in patients with acute exacerbation and remission period of daytime blood gas situation. Results: The study group of patients with acute exacerbation of P0.1 in the period of 0.446 ± 0.008 Kpa, remission period for 0.325 ± 0.105 Kpa, remission time was 13 ± 2 days. The control group of patients with acute exacerbation of P0.1 period 0.446 ± 0.002 Kpa to ease the period of 0.338 ± 0.001 Kpa, remission time was 18 ± 3 days. two acute stage of P0.1 is higher than the remission period, the difference has statistical significance (P <0.05). Remission P0.1 Study Group compared the two groups than the control group decreased, suggesting that non-invasive ventilation in the treatment of COPD patients can reduce central respiratory drive. Conclusion: The central respiratory drive in COPD acute exacerbation than in remission period increased, non-invasive mechanical ventilation for COPD patients with respiratory failure to improve the central respiratory drive may play a role.