众所周知,RNA在生命活动中具有重要的作用，它和蛋白共同负责基因的表达和表达过程的调控。近年来研究表明,一些小的双链RNA可以高效、特异的阻断体内基因表达，促进RNA降解，可在细胞内发挥基因敲除的作用，称为RNA干预（即RNAi）。它是体内抵御外在感染的一种重要保护机制。为此被Science评为2001年最重要的的成果之一。现将RNA和RNAi的近期报道和相关文献列举如下，以供参考：



RNAi-U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells

RNAi-A Short Primer on RNAi-RNA-Directed RNA Polymerase Acts as a Key Catalyst

RNAi-ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway

RNAi-Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

RNAi-Effective expression of small interfering RNA in human cells

RNAi-Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

RNAi-On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing

RNAi-RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

RNAi-Role for a bidentate ribonuclease in the initiation step of RNA interference

RNAi-U6 promoter–driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells

RNAi-Double-Stranded RNA Interference with Gene Expression-RNAi

RNAi-Interfering With Gene Expression

RNAi-Ribosome Structure and Function

RNAi-RNA Interference

RNAi-RNAi chapter in Developmental Biology

RNAi-A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

RNAi as Random Degradative PCR-siRNA Primers Convert mRNA into dsRNAs that Are Degraded to Generate New siRNAs

RNAi-Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA

RNAi-nature abhors a double-strand

RNAi-A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

RNAi-A new approach to the inhibition of gene expression

RNAi-A Short Primer on RNAi-RNA-Directed RNA Polymerase Acts as a Key Catalyst

RNAi-An exon that prevents transport of a mature mRNA

RNAi-Antisense Oligonucleotides-Basic Concepts and Mechanisms

RNAi-ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway

RNAi-Bulged residues promote the progression of a loop?§Cloop interaction to a stable and inhibitory antisense?§Ctarget RNA complex

RNAi-Combinatorial RNAi-a method for evaluating the functions of gene families

RNAi-Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

RNAi-Epigenetics-Regulation Through Repression

RNAi-Gene Activation and Gene Silencing

RNAi-Gene silencing by double-stranded RNA

RNAi-Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs

RNAi-Genome-wide RNAi

RNAI-Glimpses of a Tiny RNA World

RNAi-gt-Gene silencing as a threat to the success of gene therapy

RNAi-GTPase Ran Regulates Chromosome Positioning and Nuclear Envelope Assembly In Vivo

RNAi-Identification of Novel Genes Coding for Small Expressed RNAs

RNAi-mediated oncogene silencing confers resistance to crown gall tumorigenesis

RNAi-MicroRNAs-deviants no longer

RNAi-Non-coding RNAs-the architects of eukaryotic complexity

RNAi-Progression of a loop?§Cloop complex to a four-way junction is crucial for the activity of a regulatory antisense RNA

RNAi-Prospects for anti-ras drugs

RNAi-RNA-Guiding Gene Silencing

RNAi-RNA Interference Can Target Pre-mRNA

RNAi-RNA interference-genetic wand and genetic watchdog

RNAi-RNA interference is mediated by 21-and 22-nucleotide RNAs

RNAi-RNA interference2001

RNAi-RNAi and brain function

RNAi-RNAi and double-strand RNA

RNAi-RNAi is antagonized by A?I hyper-editing

RNAi-RNAi surges on-application to cultured mammalian cells

RNAi-RNAi-mediated oncogene silencing confers resistance to crown gall tumorigenesis

RNAi-Role for a bidentate ribonuclease in the initiation step of RNA interference

RNAi-Running interference

RNAi-Stable suppression of gene expression by RNAi in mammalian cells

RNAi-Suppression of Gene Expression by Targeted Disruption of Messenger RNA-Available Options and Current Strategies

RNAi-Suppression of Gene Expression by Targeted Disruption of Messenger RNA

RNAi-TAPping into mRNA Export

RNAi-The non-coding RNAs as riboregulators

RNAi-Transcriptional silencing and promoter methylation triggered by double-stranded RNA

RNAi-Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways

RNAi-Using RNA interference to identify genes required for RNA interference RNA-Gene Expression-A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

RNA-Gene Expression-A Unified Theory of Gene Expression

RNA-Gene Expression-Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators

RNA-Gene Expression-Cooperation between Complexes that Regulate Chromatin Structure and Transcription

RNA-Gene Expression-Epigenetic Codes for Heterochromatin Formation and Silencing-Rounding up the Usual Suspects

RNA-Gene Expression-Gene-Specific Regulation by General Translation Factors

RNA-Gene Expression-Integrating mRNA Processing with Transcription

RNA-Gene Expression-Mechanisms of Subcellular mRNA Localization

RNA-Gene Expression-Nuclear RNA Turnover

RNA-Gene Expression-Protein Folding and Unfolding at Atomic Resolution

RNA-Gene Expression-Ribosome Structure and the Mechanism of Translation

RNA-Gene Expression-The Complexities of Trypanosome RNA Editing

RNA-Gene Expression-The Contribution of Nuclear Compartmentalization to Gene Regulation

RNA-Gene Expression-The RNA Polymerase II Machinery-Structure Illuminates Function

RNA-a method to specifically inhibit PCR amplification of known members of a multigene family by degenerate primers

RNA-analysis by ion-pair reversed-phase high performance liquid chromatography

RNA-commutes to work-regulation of plant gene expression by systemically transported RNA molecules

RNA-interference2001

RNA-polymerase II and the integration of nuclear events

RNA-Targets of the Fragile X Protein

RNA-Co-transcriptional splicing of pre-messenger RNAs

RNA-Linear 2' O-Methyl RNA probes for the visualization of RNA in living cells

RNA-Messenger RNA on the move-implications for cell polarity

RNA-Micro-RNAs-small is plentiful

RNA-microRNAs-Tiny Regulators with Great Potential

RNA-mRNA Expression Analysis of Tissue Sections and Single Cells

RNA-Non-coding RNAs

RNA-Regulation of mRNA stability in mammalian cells

RNA-The cross-link from the upstream region of mRNA to ribosomal protein S7 i

RNA-A handful of intron-containing genes produces the lion's share of yeast mRNA

RNA-bi-A computational approach to identify genes for functional RNAs in genomic sequences

RNA-Coupled nucleotide covariations reveal dynamic RNA interaction patterns

RNA-DExD-H Box RNA Helicases-From Generic Motors to Specific Dissociation Functions

RNA-Genomic-scale quantitative analysis of yeast pre-mRNA splicing-Implications for splice-site recognition

RNA-Getting the Message Across-The Intracellular Localization of mRNAs in Higher Eukaryotes

RNA-Identification of Novel Genes Coding for Small Expressed RNAs

RNA-Internal ribosome entry sites in eukaryotic mRNA molecules

RNA–ligand chemistry-A testable source for the genetic code

RNA-Maximizing RNA folding rates-A balancing act

RNA-mRNA surveillance in eukaryotes

RNA-mRNA surveillance in mammalian cells-The relationship between introns and translation termination

RNA-NON-CODING RNA GENES AND THE MODERN RNA WORLD

RNA-Nuclear RNA Export Pathways

RNA-On the wobble GoU and related pairs

RNA-Quantitative analysis of mRNA amplification by in vitro transcription